Home Products DSIP
Vial of DSIP research compound with silver cap and Suria label, lit against a dark background with warm gold ambient light

Overview

A nonapeptide from classic sleep research.

DSIP (delta sleep-inducing peptide) is a nine-residue peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was characterized in 1977 by Schoenenberger and Monnier as a delta-electroencephalogram (sleep)-inducing peptide in rabbit studies, which gave the peptide its name.

Published preclinical work has examined DSIP-like immunoreactivity in brain, peripheral tissues and plasma, and the peptide's effects on electrophysiological activity, neurotransmitter levels, circadian and locomotor patterns, and hormonal parameters. Its mechanism of action remains incompletely characterized and is still described in the literature as an open question.

Suria's DSIP is offered for laboratory research.

Research Use Only. Not for human or veterinary use.

Specifications

Documented, down to the molecule.

Purity
See active-lot Certificate of Analysis
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE; 9 amino acids)
Molecular Formula
C35H48N10O15
Molecular Weight
848.81 g/mol
CAS Number
62568-57-4
Storage
−20°C, lyophilized; protect from light and moisture
Appearance
Lyophilized powder; see active-lot Certificate of Analysis
Research Category
Neuropeptide Signaling Research

Certificate of Analysis

Product documentation.

Certificate of Analysis

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Other documentation: Batch Documentation.

Research Highlights

Why researchers study it.

Sleep-EEG Research

Characterized for its association with delta-wave (slow-wave) EEG activity in animal sleep models.

Neuroendocrine Parameters

Examined in preclinical studies of hormonal levels and neurotransmitter activity.

Circadian & Locomotor Patterns

Studied for effects on circadian and locomotor activity patterns in experimental models.

Open Mechanism

Its mechanism of action remains incompletely characterized, an open question in neuropeptide research.

Selected Literature

Where the research comes from.

  1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci USA. 1977;74:1282. PMID 265572.
  2. Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984;8(1):83–93. doi:10.1016/0149-7634(84)90022-8.
  3. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006. doi:10.1111/j.1471-4159.2006.03693.x.

Literature is cited for scientific context only. Suria makes no claims regarding any use of this material outside laboratory research.

Storage

Handled the way research deserves.

Lyophilized vials

Store as specified above, protected from light and moisture, until ready for reconstitution.

Reconstituted solution

Store at 2–8°C and use within the laboratory's established handling window.

Handling

Avoid repeated freeze-thaw cycles to help preserve peptide integrity across a research protocol.

Research Use Only. Not for human consumption.

Frequently Asked Questions

Good to know before you order.

How is it shipped?
Orders are packaged with care and shipped using protective, secure methods designed to help each vial arrive in excellent condition.
How should it be stored?
Store lyophilized vials as specified above, away from light and moisture. Once reconstituted, store at 2–8°C and use within the laboratory's established handling window.
Is this for human consumption?
No. DSIP is sold strictly for laboratory and scientific research use. It is not intended for human or veterinary use, and is not a drug, dietary supplement, or food.
Why does purity matter?
Purity directly affects the reliability of research outcomes. Available analytical documentation, labelled with who issued it, can be reviewed for applicable batches through Suria's Batch Documentation system.

Batch Documentation

View available analytical documentation for this research product.

View Documentation